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mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism.
Aging Cell. 2019 Jun;18(3):e12943. doi: 10.1111/acel.12943. Epub 2019 Mar 29.
Aging Cell. 2019.
PMID: 30924297
Free PMC article.
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction.
Miller RA, Harrison DE, Astle CM, Fernandez E, Flurkey K, Han M, Javors MA, Li X, Nadon NL, Nelson JF, Pletcher S, Salmon AB, Sharp ZD, Van Roekel S, Winkleman L, Strong R.
Miller RA, et al. Among authors: van roekel s.
Aging Cell. 2014 Jun;13(3):468-77. doi: 10.1111/acel.12194. Epub 2014 Feb 9.
Aging Cell. 2014.
PMID: 24341993
Free PMC article.
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Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence.
Hinojosa CA, Mgbemena V, Van Roekel S, Austad SN, Miller RA, Bose S, Orihuela CJ.
Hinojosa CA, et al. Among authors: van roekel s.
Exp Gerontol. 2012 Dec;47(12):958-65. doi: 10.1016/j.exger.2012.08.013. Epub 2012 Sep 7.
Exp Gerontol. 2012.
PMID: 22981852
Free PMC article.
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